The Administration has developed a variant playbook to rapidly assess the disease severity and transmissibility of a new variant, and to expedite the rapid laboratory evaluation of the effectiveness of vaccines, tests, and treatments against any variant. The U.S. The Administration has developed a variant playbook to assess the disease severity and transmissibility of a new variant immediately, and to expedite the rapid laboratory evaluation of the effectiveness of vaccines, tests, and treatments against any variant. The U.S. government has also developed a series of plans in coordination with manufacturers for the accelerated development, approval, manufacturing, and delivery of updated vaccines, tests, and treatments. These expedited plans and processes suggest that updated vaccines can be deployed in 100 days instead of many months or years.